Pineapple Express (2008)

Stoner Dale Denton's (Seth Rogen) enjoyment of a rare strain of marijuana may prove fatal when he drops his roach in a panic after witnessing a murder. Upon learning that the fancy weed can be traced back to them, Dale and his dealer (James Franco) go on the lam, with a dangerous drug lord (Gary Cole) and crooked cop (Rosie Perez) hot on their heels.