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The 49ers and Lions meet in a rematch of the 2023-24 NFC championship game, won by San Francisco 34-31. Detroit is vying for the NFC North title and the No. 1 seed in the playoffs. Entering Week 17, the Lions led the NFL with 32.9 points per outing.

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Detroit Lions at San Francisco 49ers (2024)

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Detroit Lions at San Francisco 49ers (2024)