Powwow Highway (1989)

Two Cheyenne Indian friends with very different outlooks on life set off on a road trip. Philbert Bono (Gary Farmer) is a spiritual seeker trying to find the answers to life's questions; his pal, Buddy Red Bow (A Martinez), is a realist who sees the world in black-and-white terms. When Buddy's sister is jailed in Santa Fe, N.M., the mismatched duo hit the highway in Philbert's dilapidated 1964 Buick and experience wild twists and turns on their journey of self-discovery.